Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

BACKGROUND: Pilsicainide, classified as a relatively selective Na(+) channel blocker, also has an inhibitory action on the rapidly-activating delayed-rectifier K(+) current (I(Kr)) through human ether-a-go-go-related gene (hERG) channels. We studied the effects of chronic exposure to pilsicainide on...

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Detalhes bibliográficos
Publicado no:J Arrhythm
Main Authors: Onohara, Takeshi, Hisatome, Ichiro, Kurata, Yasutaka, Li, Peili, Notsu, Tomomi, Morikawa, Kumi, Otani, Naoyuki, Yoshida, Akio, Iitsuka, Kazuhiko, Kato, Masaru, Miake, Junichiro, Ninomiya, Haruaki, Higaki, Katsumi, Shirayoshi, Yasuaki, Nishihara, Takashi, Itoh, Toshiyuki, Nakamura, Yoshinobu, Nishimura, Motonobu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5459418/
https://ncbi.nlm.nih.gov/pubmed/28607619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joa.2016.09.003
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