Loss of perivascular aquaporin 4 may underlie deficient water and K(+) homeostasis in the human epileptogenic hippocampus

An abnormal accumulation of extracellular K(+) in the brain has been implicated in the generation of seizures in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Experimental studies have shown that clearance of extracellular K(+) is compromised by removal of the perivas...

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Главные авторы: Eid, Tore, Lee, Tih-Shih W., Thomas, Marion J., Amiry-Moghaddam, Mahmood, Bjørnsen, Lars P., Spencer, Dennis D., Agre, Peter, Ottersen, Ole P., de Lanerolle, Nihal C.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2005
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC545857/
https://ncbi.nlm.nih.gov/pubmed/15657133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409308102
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