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Osmotherapy with Hypertonic Saline Attenuates Global Cerebral Edema following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4

OBJECTIVE: We tested the hypothesis that osmotherapy with hypertonic saline (HS) attenuates cerebral edema following experimental cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) by exerting its effect via the perivascular pool of aquaporin-4 (AQP4). We used mice with targeted disruption...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Nakayama, Shin, Migliati, Elton, Amiry-Moghaddam, Mahmood, Ottersen, Ole P., Bhardwaj, Anish
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949130/
https://ncbi.nlm.nih.gov/pubmed/27035238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001671
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