Osmotherapy with Hypertonic Saline Attenuates Global Cerebral Edema following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4

OBJECTIVE: We tested the hypothesis that osmotherapy with hypertonic saline (HS) attenuates cerebral edema following experimental cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) by exerting its effect via the perivascular pool of aquaporin-4 (AQP4). We used mice with targeted disruption...

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Veröffentlicht in:Crit Care Med
Hauptverfasser: Nakayama, Shin, Migliati, Elton, Amiry-Moghaddam, Mahmood, Ottersen, Ole P., Bhardwaj, Anish
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949130/
https://ncbi.nlm.nih.gov/pubmed/27035238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001671
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