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Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
The proteasome holoenzyme is the major non-lysosomal protease; its proteolytic activity is essential for cellular homeostasis. Thus, it is an attractive target for the development of chemotherapeutics. While the structural basis of core particle (CP) inhibitors is largely understood, their structura...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458511/ https://ncbi.nlm.nih.gov/pubmed/28541292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15578 |
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