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The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design

Recent developments in electron microscopy (EM) have led to a step change in our ability to solve the structures of previously intractable systems, especially membrane proteins and large protein complexes. This has provided new opportunities in the field of structure-based drug design, with a number...

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Détails bibliographiques
Publié dans:Acta Crystallogr D Struct Biol
Auteurs principaux: Rawson, S., McPhillie, M. J., Johnson, R. M., Fishwick, C. W. G., Muench, S. P.
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458495/
https://ncbi.nlm.nih.gov/pubmed/28580915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317004077
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