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Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages. Long-term expression of Cas9 increases the number of genomic loci non-specifically cleaved by the nuclease. Here we develop a Self-Limiting Cas9 circuit for Enhanced Safety and specificity (SLiCES)...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458126/ https://ncbi.nlm.nih.gov/pubmed/28530235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15334 |
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