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Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR gene. The 3272–26A>G and 3849+10kbC>T CFTR mutations alter the correct splicing of the CFTR gene, generating new acceptor and donor splice sites respectively. Here we develop a genome editing approach to per...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6685978/ https://ncbi.nlm.nih.gov/pubmed/31391465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11454-9 |
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