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The Emerging Role of Homologous Recombination Repair and PARP Inhibitors in Genitourinary Malignancies
As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single or double- strand breaks. Loss of function somatic genomic aberrations or germline deficiency in genes involved in DNA repair can result in acute cell death or fo...
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| Publicado no: | Cancer |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5457906/ https://ncbi.nlm.nih.gov/pubmed/28323334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30631 |
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