Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

ABSTRACT: Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this disease. LPAs and autotaxin, the major enzyme producing extracellular LPAs, were anal...

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Publicado en:Acta Neuropathol Commun
Autores principales: Schmitz, K., Brunkhorst, R., de Bruin, N., Mayer, C. A., Häussler, A., Ferreiros, N., Schiffmann, S., Parnham, M. J., Tunaru, S., Chun, J., Offermanns, S., Foerch, C., Scholich, K., Vogt, J., Wicker, S., Lötsch, J., Geisslinger, G., Tegeder, I.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457661/
https://ncbi.nlm.nih.gov/pubmed/28578681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0446-4
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