Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

ABSTRACT: Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this disease. LPAs and autotaxin, the major enzyme producing extracellular LPAs, were anal...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Schmitz, K., Brunkhorst, R., de Bruin, N., Mayer, C. A., Häussler, A., Ferreiros, N., Schiffmann, S., Parnham, M. J., Tunaru, S., Chun, J., Offermanns, S., Foerch, C., Scholich, K., Vogt, J., Wicker, S., Lötsch, J., Geisslinger, G., Tegeder, I.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457661/
https://ncbi.nlm.nih.gov/pubmed/28578681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0446-4
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