Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

ABSTRACT: Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this disease. LPAs and autotaxin, the major enzyme producing extracellular LPAs, were anal...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Neuropathol Commun
Prif Awduron: Schmitz, K., Brunkhorst, R., de Bruin, N., Mayer, C. A., Häussler, A., Ferreiros, N., Schiffmann, S., Parnham, M. J., Tunaru, S., Chun, J., Offermanns, S., Foerch, C., Scholich, K., Vogt, J., Wicker, S., Lötsch, J., Geisslinger, G., Tegeder, I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457661/
https://ncbi.nlm.nih.gov/pubmed/28578681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0446-4
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