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Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice
Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a...
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| Publicado no: | Cell Mol Immunol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7609649/ https://ncbi.nlm.nih.gov/pubmed/31467413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0274-5 |
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