Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis

ABSTRACT: Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in multiple sclerosis (MS) and are functionally relevant in this disease. LPAs and autotaxin, the major enzyme producing extracellular LPAs, were anal...

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Udgivet i:Acta Neuropathol Commun
Main Authors: Schmitz, K., Brunkhorst, R., de Bruin, N., Mayer, C. A., Häussler, A., Ferreiros, N., Schiffmann, S., Parnham, M. J., Tunaru, S., Chun, J., Offermanns, S., Foerch, C., Scholich, K., Vogt, J., Wicker, S., Lötsch, J., Geisslinger, G., Tegeder, I.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457661/
https://ncbi.nlm.nih.gov/pubmed/28578681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0446-4
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