Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

Binary enterotoxins Clostridium (C.) botulinum C2 toxin, C. perfringens iota toxin and C. difficile toxin CDT are composed of a transport (B) and a separate non-linked enzyme (A) component. Their B-components mediate endocytic uptake into mammalian cells and subsequently transport of the A-component...

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Publicado no:Sci Rep
Main Authors: Ernst, Katharina, Schmid, Johannes, Beck, Matthias, Hägele, Marlen, Hohwieler, Meike, Hauff, Patricia, Ückert, Anna Katharina, Anastasia, Anna, Fauler, Michael, Jank, Thomas, Aktories, Klaus, Popoff, Michel R., Schiene-Fischer, Cordelia, Kleger, Alexander, Müller, Martin, Frick, Manfred, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457432/
https://ncbi.nlm.nih.gov/pubmed/28578412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02882-y
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