Multinuclear NMR and MRI reveal an early metabolic response to mTOR inhibition in sarcoma

Biomarkers predicting rapalog responses in sarcomas where PI3K and mTOR are often hyperactivated could improve the suitable recruitment of responsive patients to clinical trials. PI3K/mTOR pathway activation drives energy production by regulating anaerobic glycolysis in cancer cells, suggesting a ro...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Di Gialleonardo, Valentina, Aldeborgh, Hannah N., Miloushev, Vesselin, Folkers, Kelly M., Granlund, Kristin, Tap, William D., Lewis, Jason S., Weber, Wolfgang A., Keshari, Kayvan R.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457322/
https://ncbi.nlm.nih.gov/pubmed/28386017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3310
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