Hyperpolarized MRI visualizes Warburg effects and predicts treatment response to mTOR inhibitors in patient-derived ccRCC xenograft models

The ever-changing tumor-microenvironment constantly challenges individual cancer cells to balance supply and demand, presenting tumor vulnerabilities and therapeutic opportunities. Everolimus and temsirolimus are inhibitors of mTOR (mTORi) approved for treating metastatic renal cell carcinoma (mRCC)...

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Vydáno v:Cancer Res
Hlavní autoři: Dong, Yiyu, Eskandari, Roozbeh, Ray, Chelsea, Granlund, Kristin L., Santos-Cunha, Lidia Dos, Miloushev, Vesselin Z., Tee, Sui Seng, Jeong, Sangmoo, Aras, Omer, Chen, Ying-Bei, Cheng, Emily H., Hsieh, James J., Keshari, Kayvan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318024/
https://ncbi.nlm.nih.gov/pubmed/30459151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2231
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