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Multinuclear NMR and MRI reveal an early metabolic response to mTOR inhibition in sarcoma

Biomarkers predicting rapalog responses in sarcomas where PI3K and mTOR are often hyperactivated could improve the suitable recruitment of responsive patients to clinical trials. PI3K/mTOR pathway activation drives energy production by regulating anaerobic glycolysis in cancer cells, suggesting a ro...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Di Gialleonardo, Valentina, Aldeborgh, Hannah N., Miloushev, Vesselin, Folkers, Kelly M., Granlund, Kristin, Tap, William D., Lewis, Jason S., Weber, Wolfgang A., Keshari, Kayvan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457322/
https://ncbi.nlm.nih.gov/pubmed/28386017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3310
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