Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease

Loss of Norrin signalling due to mutations in the Norrie disease pseudoglioma gene causes severe vascular defects in the retina, leading to visual impairment and ultimately blindness. While the emphasis of experimental work so far was on the developmental period, we focus here on disease mechanisms...

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Bibliographic Details
Published in:PLoS One
Main Authors: Beck, Susanne C., Feng, Yuxi, Sothilingam, Vithiyanjali, Garcia Garrido, Marina, Tanimoto, Naoyuki, Acar, Niyazi, Shan, Shenliang, Seebauer, Britta, Berger, Wolfgang, Hammes, Hans-Peter, Seeliger, Mathias W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456345/
https://ncbi.nlm.nih.gov/pubmed/28575130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178753
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