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Mutational Alterations of the Key cis Proline Residue That Cause Accumulation of Enzymatic Reaction Intermediates of DsbA, a Member of the Thioredoxin Superfamily

The DsbA-DsbB pathway introduces disulfide bonds into newly translocated proteins. Conversion of the conserved cis proline 151 of DsbA to several hydrophilic residues results in accumulation of mixed disulfides between DsbA and its dedicated oxidant, DsbB. However, only a proline-to-threonine change...

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Bibliographic Details
Main Authors: Kadokura, Hiroshi, Nichols, Lorenzo, Beckwith, Jon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545618/
https://ncbi.nlm.nih.gov/pubmed/15687218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.4.1519-1522.2005
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