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Mutational Alterations of the Key cis Proline Residue That Cause Accumulation of Enzymatic Reaction Intermediates of DsbA, a Member of the Thioredoxin Superfamily

The DsbA-DsbB pathway introduces disulfide bonds into newly translocated proteins. Conversion of the conserved cis proline 151 of DsbA to several hydrophilic residues results in accumulation of mixed disulfides between DsbA and its dedicated oxidant, DsbB. However, only a proline-to-threonine change...

詳細記述

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書誌詳細
主要な著者: Kadokura, Hiroshi, Nichols, Lorenzo, Beckwith, Jon
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC545618/
https://ncbi.nlm.nih.gov/pubmed/15687218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.4.1519-1522.2005
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