Contribution of the ATP Binding Site of ParE to Susceptibility to Novobiocin and Quinolones in Streptococcus pneumoniae

In Streptococcus pneumoniae, an H103Y substitution in the ATP binding site of the ParE subunit of topoisomerase IV was shown to confer quinolone resistance and hypersensitivity to novobiocin when associated with an S84F change in the A subunit of DNA gyrase. We reconstituted in vitro the wild-type t...

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Veröffentlicht in:J Bacteriol
Hauptverfasser: Dupont, Philippe, Aubry, Alexandra, Cambau, Emmanuelle, Gutmann, Laurent
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2005
Schlagworte:
Genetics and Molecular Biology
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545609/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15687222/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.187.4.1536-1540.2005
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