Contribution of the ATP Binding Site of ParE to Susceptibility to Novobiocin and Quinolones in Streptococcus pneumoniae

In Streptococcus pneumoniae, an H103Y substitution in the ATP binding site of the ParE subunit of topoisomerase IV was shown to confer quinolone resistance and hypersensitivity to novobiocin when associated with an S84F change in the A subunit of DNA gyrase. We reconstituted in vitro the wild-type t...

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Detalles Bibliográficos
Publicado en:J Bacteriol
Autores principales: Dupont, Philippe, Aubry, Alexandra, Cambau, Emmanuelle, Gutmann, Laurent
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2005
Materias:
Genetics and Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545609/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15687222/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.187.4.1536-1540.2005
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