A reverse genetic screen in Drosophila using a deletion-inducing mutagen

We report the use of the cross-linking drug hexamethylphosphoramide (HMPA), which introduces small deletions, as a mutagen suitable for reverse genetics in the model organism Drosophila melanogaster. A compatible mutation-detection method based on resolution of PCR fragment-length polymorphisms on s...

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Bibliografiske detaljer
Main Authors: Nairz, Knud, Zipperlen, Peder, Dearolf, Charles, Basler, Konrad, Hafen, Ernst
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545603/
https://ncbi.nlm.nih.gov/pubmed/15461801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2004-5-10-r83
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