Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kang, Sohye, Bader, Andreas G., Vogt, Peter K.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2005
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545580/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15647370/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408864102
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