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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-kinase) signaling pathway are common in human cancer. The recent discovery of nonrandom somatic mutations in the PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545580/ https://ncbi.nlm.nih.gov/pubmed/15647370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408864102 |
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