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Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants

Defects in meiotic recombination in many organisms result in arrest because of activation of a meiotic checkpoint(s). The proximal defect that triggers this checkpoint in mammalian germ cells is not understood, but it has been suggested to involve either the presence of DNA damage in the form of unr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Di Giacomo, Monica, Barchi, Marco, Baudat, Frédéric, Edelmann, Winfried, Keeney, Scott, Jasin, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545532/
https://ncbi.nlm.nih.gov/pubmed/15640358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406212102
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