The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma

The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC oncogenes activate both proliferative and apoptotic cellular pathways and, accordingly, inhibition of p53-mediated apoptos...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Slack, Andrew, Chen, Zaowen, Tonelli, Roberto, Pule, Martin, Hunt, Lisa, Pession, Andrea, Shohet, Jason M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC545522/
https://ncbi.nlm.nih.gov/pubmed/15644444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405495102
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