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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC oncogenes activate both proliferative and apoptotic cellular pathways and, accordingly, inhibition of p53-mediated apoptos...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545522/ https://ncbi.nlm.nih.gov/pubmed/15644444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405495102 |
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