Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo

The role of endothelium-derived nitric oxide (NO) in acute inflammation is not known. Here, we examine acute inflammation in congenic endothelial NO synthase-deficient (eNOS(-/-)) mice. Intraplantar injection of carrageenan induces a biphasic inflammatory response. The early phase (0-6 h) is largely...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Bucci, Mariarosaria, Roviezzo, Fiorentina, Posadas, Inmaculada, Yu, Jun, Parente, Luca, Sessa, William C., Ignarro, Louis J., Cirino, Giuseppe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
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Biological Sciences
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15640348/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408906102
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