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Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

The impairment of autophagic and proteasomal cleansing together with changes in pigmentation has been documented in retinal pigment epithelial (RPE) cell degeneration. However, the function and co-operation of these mechanisms in melanosome-containing RPE cells is still unclear. We show that inhibit...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autores principales: Juuti-Uusitalo, Kati, Koskela, Ali, Kivinen, Niko, Viiri, Johanna, Hyttinen, Juha M. T., Reinisalo, Mika, Koistinen, Arto, Uusitalo, Hannu, Sinha, Debasish, Skottman, Heli, Kaarniranta, Kai
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454998/
https://ncbi.nlm.nih.gov/pubmed/28534814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18051089
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