Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

The impairment of autophagic and proteasomal cleansing together with changes in pigmentation has been documented in retinal pigment epithelial (RPE) cell degeneration. However, the function and co-operation of these mechanisms in melanosome-containing RPE cells is still unclear. We show that inhibit...

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Publié dans:Int J Mol Sci
Auteurs principaux: Juuti-Uusitalo, Kati, Koskela, Ali, Kivinen, Niko, Viiri, Johanna, Hyttinen, Juha M. T., Reinisalo, Mika, Koistinen, Arto, Uusitalo, Hannu, Sinha, Debasish, Skottman, Heli, Kaarniranta, Kai
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454998/
https://ncbi.nlm.nih.gov/pubmed/28534814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18051089
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