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Autophagy Regulates Proteasome Inhibitor-Induced Pigmentation in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells

The impairment of autophagic and proteasomal cleansing together with changes in pigmentation has been documented in retinal pigment epithelial (RPE) cell degeneration. However, the function and co-operation of these mechanisms in melanosome-containing RPE cells is still unclear. We show that inhibit...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Juuti-Uusitalo, Kati, Koskela, Ali, Kivinen, Niko, Viiri, Johanna, Hyttinen, Juha M. T., Reinisalo, Mika, Koistinen, Arto, Uusitalo, Hannu, Sinha, Debasish, Skottman, Heli, Kaarniranta, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454998/
https://ncbi.nlm.nih.gov/pubmed/28534814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18051089
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