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Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury from drug hepatotoxicity (whether idiosyncratic or predictable) results in hepatocyte cell death and inflammation. Th...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Iorga, Andrea, Dara, Lily, Kaplowitz, Neil
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454931/
https://ncbi.nlm.nih.gov/pubmed/28486401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18051018
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