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Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms...

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Pubblicato in:Int J Mol Sci
Autori principali: Brings, Sebastian, Fleming, Thomas, Freichel, Marc, Muckenthaler, Martina U., Herzig, Stephan, Nawroth, Peter P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454897/
https://ncbi.nlm.nih.gov/pubmed/28475116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18050984
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