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Mistranslation can enhance fitness through purging of deleterious mutations
Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5454534/ https://ncbi.nlm.nih.gov/pubmed/28524864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15410 |
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