Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy

Ribonucleotide reductase (RR) is the rate-limiting enzyme in DNA synthesis, catalyzing the reduction of ribonucleotides to deoxyribonucleotides. During each enzymatic turnover, reduction of the active site disulfide in the catalytic large subunit is performed by a pair of shuttle cysteine residues i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lou, Meng, Liu, Qian, Ren, Guoping, Zeng, Jiling, Xiang, Xueping, Ding, Yongfeng, Lin, Qinghui, Zhong, Tingting, Liu, Xia, Zhu, Lijun, Qi, Hongyan, Shen, Jing, Li, Haoran, Shao, Jimin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454097/
https://ncbi.nlm.nih.gov/pubmed/28411237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783365
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