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Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1

Hrd1 is the core structural component of a large endoplasmic reticulum membrane-embedded protein complex that coordinates the destruction of folding-defective proteins in the early secretory pathway. Defining the composition, dynamics, and ultimately, the structure of the Hrd1 complex is a crucial s...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Hwang, Jiwon, Walczak, Christopher P., Shaler, Thomas A., Olzmann, James A., Zhang, Lichao, Elias, Joshua E., Kopito, Ron R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454095/
https://ncbi.nlm.nih.gov/pubmed/28411238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785055
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