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Mutational and computational evidence that a nickel-transfer tunnel in UreD is used for activation of Klebsiella aerogenes urease

Nickel-containing urease from Klebsiella aerogenes requires four accessory proteins for proper active site metalation. The metallochaperone UreE delivers nickel to UreG, a GTPase that forms a UreD:UreF:UreG complex which binds to urease apoprotein via UreD. Prior in silico analysis of the homologous...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Farrugia, Mark A., Wang, Beibei, Feig, Michael, Hausinger, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453724/
https://ncbi.nlm.nih.gov/pubmed/26401965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00942
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