Hyper‐reactive cloned mice generated by direct nuclear transfer of antigen‐specific CD4(+) T cells

T‐cell receptor (TCR)‐transgenic mice have been employed for evaluating antigen‐response mechanisms, but their non‐endogenous TCR might induce immune response differently than the physiologically expressed TCR. Nuclear transfer cloning produces animals that retain the donor genotype in all tissues i...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kaminuma, Osamu, Katayama, Kazufumi, Inoue, Kimiko, Saeki, Mayumi, Nishimura, Tomoe, Kitamura, Noriko, Shimo, Yusuke, Tofukuji, Soichi, Ishida, Satoru, Ogonuki, Narumi, Kamimura, Satoshi, Oikawa, Mami, Katoh, Shigeki, Mori, Akio, Shichijo, Michitaka, Hiroi, Takachika, Ogura, Atsuo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452041/
https://ncbi.nlm.nih.gov/pubmed/28468955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643321
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