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BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells

In the present study, we investigated the effect of bone morphogenetic protein 4 (BMP4) on PDGF-induced cell proliferation and collagen synthesis in pulmonary artery smooth muscle cells (PASMCs). Normal human PASMCs were incubated with and without PDGF-BB in the absence and presence of BMP4 for 0.5...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Am J Physiol Lung Cell Mol Physiol
Main Authors: Cai, Pengcheng, Kovacs, Laszlo, Dong, Sam, Wu, Guangyu, Su, Yunchao
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451598/
https://ncbi.nlm.nih.gov/pubmed/28235949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00260.2016
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