Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling

Endothelial cell (EC) activation and vascular injury are hallmark features of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Caveolin-1 (Cav-1) is highly expressed in pulmonary microvascular ECs and plays a key role in maintaining vascular homeostasis. The aim of this study...

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Udgivet i:Am J Physiol Lung Cell Mol Physiol
Main Authors: Oliveira, Suellen D. S., Castellon, Maricela, Chen, Jiwang, Bonini, Marcelo G., Gu, Xiaowu, Elliott, Michael H., Machado, Roberto F., Minshall, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451590/
https://ncbi.nlm.nih.gov/pubmed/28188225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00484.2016
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