Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk

Gout is caused by hyperuricemia, with alcohol consumption being an established risk factor. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are crucial enzymes for alcohol metabolism. We recently performed a genome-wide association study of gout and a subsequent fine-mapping study whic...

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Publicado en:Sci Rep
Autores principales: Sakiyama, Masayuki, Matsuo, Hirotaka, Akashi, Airi, Shimizu, Seiko, Higashino, Toshihide, Kawaguchi, Makoto, Nakayama, Akiyoshi, Naito, Mariko, Kawai, Sayo, Nakashima, Hiroshi, Sakurai, Yutaka, Ichida, Kimiyoshi, Shimizu, Toru, Ooyama, Hiroshi, Shinomiya, Nariyoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451470/
https://ncbi.nlm.nih.gov/pubmed/28566767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02528-z
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