Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk

Gout is caused by hyperuricemia, with alcohol consumption being an established risk factor. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are crucial enzymes for alcohol metabolism. We recently performed a genome-wide association study of gout and a subsequent fine-mapping study whic...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sakiyama, Masayuki, Matsuo, Hirotaka, Akashi, Airi, Shimizu, Seiko, Higashino, Toshihide, Kawaguchi, Makoto, Nakayama, Akiyoshi, Naito, Mariko, Kawai, Sayo, Nakashima, Hiroshi, Sakurai, Yutaka, Ichida, Kimiyoshi, Shimizu, Toru, Ooyama, Hiroshi, Shinomiya, Nariyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451470/
https://ncbi.nlm.nih.gov/pubmed/28566767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02528-z
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