Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk

Gout is caused by hyperuricemia, with alcohol consumption being an established risk factor. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are crucial enzymes for alcohol metabolism. We recently performed a genome-wide association study of gout and a subsequent fine-mapping study whic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sakiyama, Masayuki, Matsuo, Hirotaka, Akashi, Airi, Shimizu, Seiko, Higashino, Toshihide, Kawaguchi, Makoto, Nakayama, Akiyoshi, Naito, Mariko, Kawai, Sayo, Nakashima, Hiroshi, Sakurai, Yutaka, Ichida, Kimiyoshi, Shimizu, Toru, Ooyama, Hiroshi, Shinomiya, Nariyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451470/
https://ncbi.nlm.nih.gov/pubmed/28566767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02528-z
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