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Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates

(211)At is a most promising radionuclide for targeted alpha therapy. However, its limited availability and poorly known basic chemistry hamper its use. Based on the analogy with iodine, labelling is performed via astatobenzoate conjugates, but in vivo deastatination occurs, particularly when the con...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Teze, David, Sergentu, Dumitru-Claudiu, Kalichuk, Valentina, Barbet, Jacques, Deniaud, David, Galland, Nicolas, Maurice, Rémi, Montavon, Gilles
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451414/
https://ncbi.nlm.nih.gov/pubmed/28566709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02614-2
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