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Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I(2) receptor agonist phenyzoline in adult male rats

RATIONALE: Emerging evidence suggests the potential utility of combining opioids with imidazoline I(2) receptor agonists for chronic pain. However, chronic pain management requires prolonged pharmacotherapy and the consequence of such combination therapy remains unclear. OBJECTIVE: This study examin...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Psychopharmacology (Berl)
Main Authors: Thorn, David A., Zhang, Yanan, Li, Jun-Xu
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451304/
https://ncbi.nlm.nih.gov/pubmed/28314949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4599-4
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