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Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I(2) receptor agonist phenyzoline in adult male rats

RATIONALE: Emerging evidence suggests the potential utility of combining opioids with imidazoline I(2) receptor agonists for chronic pain. However, chronic pain management requires prolonged pharmacotherapy and the consequence of such combination therapy remains unclear. OBJECTIVE: This study examin...

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Bibliografiske detaljer
Udgivet i:Psychopharmacology (Berl)
Main Authors: Thorn, David A., Zhang, Yanan, Li, Jun-Xu
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451304/
https://ncbi.nlm.nih.gov/pubmed/28314949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4599-4
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