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Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I(2) receptor agonist phenyzoline in adult male rats
RATIONALE: Emerging evidence suggests the potential utility of combining opioids with imidazoline I(2) receptor agonists for chronic pain. However, chronic pain management requires prolonged pharmacotherapy and the consequence of such combination therapy remains unclear. OBJECTIVE: This study examin...
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| Publicat a: | Psychopharmacology (Berl) |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5451304/ https://ncbi.nlm.nih.gov/pubmed/28314949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-017-4599-4 |
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