Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in drug-resistant epilepsy. The high-mobility group box 1 (HMGB1)/TLR4 axis is a key initiator of neuroinflammation follo...

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Pubblicato in:J Clin Invest
Autori principali: Walker, Lauren Elizabeth, Frigerio, Federica, Ravizza, Teresa, Ricci, Emanuele, Tse, Karen, Jenkins, Rosalind E., Sills, Graeme John, Jorgensen, Andrea, Porcu, Luca, Thippeswamy, Thimmasettappa, Alapirtti, Tiina, Peltola, Jukka, Brodie, Martin J., Park, Brian Kevin, Marson, Anthony Guy, Antoine, Daniel James, Vezzani, Annamaria, Pirmohamed, Munir
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451237/
https://ncbi.nlm.nih.gov/pubmed/28504645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92001
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