Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies

A refined kainate (KA) C57BL/6J mouse model of status epilepticus (SE) using a repeated low dose (RLD) of KA (5 mg/kg, intraperitoneal; at 30 min intervals) was compared with the established single high dose (SHD) of KA (20 mg/kg, intraperitoneal) model. In the RLD group, increased duration of convu...

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Detalhes bibliográficos
Main Authors: Tse, Karen, Puttachary, Sreekanth, Beamer, Edward, Sills, Graeme J., Thippeswamy, Thimmasettappa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011859/
https://ncbi.nlm.nih.gov/pubmed/24802808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096622
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