Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures

More efficient or translationally relevant approaches are needed to model acquired temporal lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding and maintaining transgenic, knock-in, or knock-out lines places a high value on the efficiency of induction and anima...

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Publicado en:Exp Neurol
Autores principales: Umpierre, Anthony D., Bennett, Isaiah V., Nebeker, Lismore D., Newell, Thomas G., Tian, Bruce B., Thomson, Kyle E., White, H. Steve, White, John A., Wilcox, Karen S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382800/
https://ncbi.nlm.nih.gov/pubmed/26896834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.02.014
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